Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5570 |
| PDBID: | 7X7U |
| Chains: | CD_G |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.77 |
| Reference: | 10.1073/pnas.2204256119 |
| Antibody | |
| Antibody: | X01 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 Delta spike glycoprotein RBD |
| Antigen mutation: | Yes |
| Durg Target: | P0DTC2; P0DTC2; P0DTC2; |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >7X7U_C|Chain G[auth C]|X01 heavy chain|Mus musculus (10090) EIQLQQSGPELVAPGASVKVSCKASGYAFTSYNMYWVRQSHGKSLEWIGYIVPYNGGTTYNQEFKGKATLTVDKSSNTAYIHLNSLTSEDSAVYYCAKEGTYYGYDGVLADWGQGTLVT |
Light Chain: D
Mutation: NULL
| >7X7U_D|Chain F[auth D]|X01 light chain|Mus musculus (10090) DIQMTQSSSYLSVSLGGRVTITCKASDHINNWLAWYQQKPGNAPRLLISGVTNLETGVPSRFSGSGSGKNFTLSIASLQTEDVATYYCQQYWSFPWTFGGGTKLEIR |
Antigen
Chain: G
Mutation: L129R/T155K
| >7X7U_G|Chain A[auth G]|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) ESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition D: ASN30 ASN31 TRP32 GLY50 VAL51 ASN53 THR56 TRP92 SER93 PHE94 C: THR30 SER31 TYR32 ASN33 TYR54 GLU99 GLY100 THR101 TYR102 TYR103 GLY104 TYR105 ASP106 G: TYR369 ASN370 SER371 ALA372 PHE374 SER375 THR376 PHE377 LYS378 CYS379 TYR380 SER383 PRO384 THR385 GLY404 ASP405 VAL407 ARG408 PRO412 GLY413 GLN414 THR415 ASP427 VAL503 GLY504 TYR508 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
