Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5565 |
| PDBID: | 7X7O |
| Chains: | EF_C |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.75 |
| Reference: | 10.1080/19420862.2022.2072455 |
| Antibody | |
| Antibody: | UT28K Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2 |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >7X7O_E|Chain E, G, H, J|UT28K Fab, heavy chain|Homo sapiens (9606) MDWIWRILFLVGAATGAHSQMQLVQSGPEVKKPGTSVKVSCKASGFTFSISAVQWVRQARGQRLEWIGWIVVGSGNTNYAQKFQERVTITRDMSTSTAYMELSSLRFEDTAVYYCAAPYCGGDCSDGFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSGSSGHHHHHHHHHH |
Light Chain: F
Mutation: NULL
| >7X7O_F|Chain F, I, K, L|UT28K Fab, light chain|Homo sapiens (9606) METPAQLLFLLLLWLPDTTGEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >7X7O_C|Chain A, B, C, D|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) PTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition E: ILE31 SER32 ALA33 TRP50 VAL52 GLY54 SER55 ASN57 PRO99 GLY103 ASP104 CYS105 SER106 ASP107 GLY108 PHE109 F: SER32 TYR33 TYR92 GLY93 TRP97 C: LYS417 LEU455 PHE456 TYR473 GLN474 ALA475 GLY476 SER477 THR478 CYS480 GLU484 GLY485 PHE486 ASN487 CYS488 TYR489 PHE490 GLN493 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
