Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5548 |
| PDBID: | 7X6L |
| Chains: | HL_C |
| Organism: | Homo sapiens, Influenza A virus (A/Hong Kong/1/1968(H3N2)), Influenza A virus |
| Method: | EM |
| Resolution (Å): | 3.70 |
| Reference: | 10.1038/s41467-022-29950-w |
| Antibody | |
| Antibody: | 28-12 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus HongKong/01/1968 H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7X6L_H|Chain A[auth G], E[auth H], I|Heavy chain of antibody 12 fab|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTFSTYNMNWVRQAPGKGLEWLSYISTSSNTIYYADSVKGRFTISRDNAKNSLFLQMNSLRDEDTAVYYCARDRGCSSTNCYVVGYYFYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVE |
Light Chain: L
Mutation: NULL
| >7X6L_L|Chain B[auth J], F[auth K], J[auth L]|The light chain of the antibody 12 fab|Homo sapiens (9606) DIQMTQSPSSVSASVGDRVTITCRASQGISSYLAWYQLKPGRAPKLLIYGATRLQSGVPSRFSGSGSGTDFTLTISGLQPEDFATYHCQQADSFPLTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >7X6L_C|Chain C[auth A], G[auth C], K[auth D]|Hemagglutinin|Influenza A virus (A/Hong Kong/1/1968(H3N2)) (506350) QDLPGNDNPTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER103 SER104 THR105 L: ARG53 SER65 SER67 GLY68 THR69 ASP70 C: ASP31 ASP32 GLN33 GLU35 PRO324 GLU325 LYS326 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
