Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5531 |
| PDBID: | 7X3D |
| Chains: | HL_B |
| Organism: | Coxsackievirus B1, Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.48 |
| Reference: | 10.1016/j.chom.2022.08.001 |
| Antibody | |
| Antibody: | 9A3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Coxsackievirus B1 mature virion VP2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7X3D_H|Chain E[auth H]|9A3 heavy chain|Mus musculus (10090) EVKLVESGGGLVQPGGSLSLSCAASGFTFTDYYMNWVRQPSGKALEWLGFLRNKANGYTTEYSASVKGRFTISRDNSQSILYLQMNALRAEDSATYYCARSRYYGGTYRYALDYWGQGTSVTVS |
Light Chain: L
Mutation: NULL
| >7X3D_L|Chain F[auth L]|9A3 light chain|Mus musculus (10090) ENVLTQSPPIMSASPGEKVTMTCRASSSVSSSYLHWYQQKSGASPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISSVEAEDAATYYCQQFSGYPLTFGAGTKLELK |
Antigen
Chain: B
Mutation: NULL
| >7X3D_B|Chain B|VP2|Coxsackievirus B1 (12071) SPSAEECGYSDRVRSITLGNSTITTQECANVVVGYGVWPEYLKDNEATAEDQPTQPDVATCRFYTLESVQWMKNSAGWWWKLPDALSQMGLFGQNMQYHYLGRTGYTIHVQCNASKFHQGCLLVVCVPEAEMGCSNLNNTPEFSELSGGDSARMFTDTQVGESNAKKVQTAVWNAGMGVGVGNLTIFPHQWINLRTNNSATLVMPYINSVPMDNMFRHNNLTLMIIPFVPLNYSEGSSPYVPITVTIAPMCAEYNGLRLASNQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASP31 TYR33 PHE50 ARG52 ASN53 LYS54 ALA55 ASN56 GLY57 THR59 THR60 GLU61 TYR62 SER63 ALA64 LYS67 TYR103 TYR108 TYR110 L: PHE92 SER93 GLY94 TYR95 B: GLN70 MET72 ASN74 SER75 ALA76 MET154 PHE155 THR156 ASP157 THR158 GLN159 VAL160 GLY161 GLU162 SER163 ASN164 LYS167 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
