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Entry information

Complex
AACDB_ID: 5527
PDBID: 7X2T
Chains: HL_C
Organism: Mus musculus, Coxsackievirus B1
Method: EM
Resolution (Å): 3.69
Reference: 10.1016/j.chom.2022.08.001
Antibody
Antibody: 8A10 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Coxsackievirus B1 mature virion VP3
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Heavy Chain: H
Mutation: NULL

>7X2T_H|Chain B[auth H]|8A10 heavy chain|Mus musculus (10090)
QVQLQQSAAELARPGASVKMSCKASGYTFTTYTMHWVKQRPGQGLEWIGYINPSSRYTEYNQKFKDKTTLTADKSSSTAYMQLSSLTFEDSAVYYCARRSEADRFVYWGQGTLVTVSA

Light Chain: L
Mutation: NULL

>7X2T_L|Chain A[auth L]|8A10 light chain|Mus musculus (10090)
DIQMTQTKSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGSVKLLIYYTSTLHSGVPSRFSGSGSGTDYSLTINSLEQEDIATYFCQQGNTFPFTFGGGTKLEIRR

Antigen

Chain: C
Mutation: NULL

>7X2T_C|Chain E[auth C]|VP3|Coxsackievirus B1 (12071)
GLPVMTTPGSTQFLTSDDFQSPSAMPQFDVTPEMQIPGRVNNLMEIAEVDSVVPVNNTEDNVSSLKAYQIPVQSNSDNGKQVFGFPLQPGANNVLNRTLLGEILNYYTHWSGSIKLTFMFCGSAMATGKFLLAYSPPGAGVPKNRKDAMLGTHVIWDVGLQSSCVLCVPWISQTHYRYVVEDEYTAAGYVTCWYQTNIVVPADVQSSCDILCFVSACNDFSVRMLKDTPFIRQDTFYQ

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

L: TYR32 LEU46 TYR49 TYR50 THR53 HIS55 SER56

H: VAL2 TYR27 TYR32 SER54 SER55 ARG56 LYS74 SER75 ARG98 SER100 GLU101 ARG104 VAL106 TYR107

C: GLU59 ASP60 VAL62 SER63 ARG232 GLN233 ASP234 THR235 PHE236 TYR237 GLN238

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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