Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 552 |
| PDBID: | 3JCX |
| Chains: | HL_A |
| Organism: | Canine parvovirus, Rattus norvegicus |
| Method: | EM |
| Resolution (Å): | 4.10 |
| Reference: | 10.1128/JVI.01112-16 |
| Antibody | |
| Antibody: | E Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Capsid protein 2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3JCX_H|Chain B[auth H]|Fab E heavy chain|Rattus norvegicus (10116) SGPGLVQPSQTLSLTCTVSGFSLSSYHVHWVRQPPGKGLEWLGVMWNDGDTSYNLALNSRLSISRDTSKSQVFFKMSSLQTEDTATYYCARPELPGLTYGVWFPYWGQGTLVTVS |
Light Chain: L
Mutation: NULL
| >3JCX_L|Chain C[auth L]|Fab E light chain|Rattus norvegicus (10116) LMTQIPASMSISVGDRVTMNCKASQNVDSNVDWYQQKTGQSPNLLIYKASNRNTGVPDRFTGSGSGTDFTFTISNMQAEDLAVYYCMQSTSYPLTFGSGTKLEIKRA |
Antigen
Chain: A
Mutation: NULL
| >3JCX_A|Chain A|Capsid protein 2|Canine parvovirus (10788) MSDGAVQPDGGQPAVRNERATGSGNGSGGGGGGGSGGVGISTGTFNNQTEFKFLENGWVYITANSSRLVHLNMPESENYRRVVVNNMDKTAVNGNMALDDIHAEIVTPWSLVDANAWGVWFNPGDWQLIVNTMSELHLVSFEQEIFNVVLKTVSESATQPPTKVYNNDLTASLMVALDSNNTMPFTPAAMRSETLGFYPWKPTIPTPWRYYFQWDRTLIPSHTGTSGTPTNIYHGTDPDDVQFYTIENSVPVHLLRTGDEFATGTFFFDCKPCRLTHTWQTNRALGLPPFLNSLPQSEGDTNFGDIGVQQDKRRGVTQMGNTNYITEATIMRPAEVGYSAPYYSFEASTQGPFKTPIAAGRGGAQTDENQAADGNPRYAFGRQHGQKTTTTGETPERFTYIAHQDTGRYPEGDWIQNINFNLPVTNDNVLLPTDPIGGKTGINYTNIFNTYGPLTALNNVPPVYPNGQIWDKEFDTDLKPRLHVNAPFVCQNNCPGQLFVKVAPNLTNQYDPDASANMSRIVTYSDFWWKGKLVFKAKLRASHTWNPIQQMSINVDNQFNYVPSNIGGMKIVYEKSQLAPRKLY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: LEU130 SER131 TRP153 ASN154 ASP155 ARG198 LEU201 PRO202 GLY203 LEU204 THR205 TYR206 TRP209 L: ASP28 LYS48 A: ARG81 ASN85 MET87 ASP88 ALA91 THR228 PRO229 THR230 ASN231 ILE232 TYR233 HIS234 GLY235 THR236 PRO238 VAL241 PHE243 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
