Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 547 |
| PDBID: | 3JBF |
| Chains: | 7_3 |
| Organism: | Human poliovirus 1 Mahoney, Camelus dromedarius |
| Method: | EM |
| Resolution (Å): | 4.80 |
| Reference: | 10.1128/JVI.03017-15 |
| Antibody | |
| Antibody: | PVSP19B VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | poliovirus capsid protein VP3 |
| Antigen mutation: | No |
| Durg Target: | P03300 |
Sequence information
Antibody
Chain: 7
Mutation: NULL
| >3JBF_7|Chain E[auth 7]|nanobody VHH PVSP19B|Camelus dromedarius (9838) QVQLQESGGGSVQAGGSLTLSCAASGITYCMGWYRQVRGKEREGVAFIKTNDGTTDYADSVKGRFTISQNHATKTVYLQMNSLKPEDTAAYYCAATWRWSCPLDPEGYQYWGQGTQVTVSSHHHHHH |
Antigen
Chain: 3
Mutation: NULL
| >3JBF_3|Chain C[auth 3]|Capsid protein VP3|Human poliovirus 1 Mahoney (12081) GLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDDPILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFLFCGSMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGLQSSCTMVVPWISNTTYRQTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition 7: LYS49 ASP52 THR54 TRP97 TRP99 3: SER91 ILE180 ASP181 ASP182 SER183 PHE184 THR229 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
