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Entry information

Complex
AACDB_ID: 5460
PDBID: 7WS7
Chains: GF_B
Organism: Severe acute respiratory syndrome coronavirus 2, Homo sapiens
Method: EM
Resolution (Å): 3.40
Reference: 10.1016/j.celrep.2022.110770
Antibody
Antibody: 510A5 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: SARS-CoV-2 WT spike glycoprotein up RBD
Antigen mutation: No
Durg Target: P0DTC2; P0DTC2;

Sequence information

Antibody

Heavy Chain: G
Mutation: NULL

>7WS7_G|Chain C[auth G], E[auth K]|510A5 heavy chain|Homo sapiens (9606)
EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSGISWNSDSIDYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKDRGYEILTPASFDYWGQGTLVTVSSAS

Light Chain: F
Mutation: NULL

>7WS7_F|Chain B[auth F], D[auth J]|510A5 light chain|Homo sapiens (9606)
DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWFQHKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPPYTFGQGTKLEIK

Antigen

Chain: B
Mutation: NULL

>7WS7_B|Chain A[auth B]|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049)
IVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKS

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

F: TYR32 TYR49 GLY50 SER91 TYR92 SER93 THR94

G: ASP31 TYR32 TRP53 SER57 ARG100 GLY101 TYR102 GLU103 ILE104 LEU105 THR106 PRO107 ALA108

B: THR345 ARG346 ASN439 ASN440 LEU441 ASP442 SER443 LYS444 VAL445 ASN448 ASN450 TYR451 PRO499 THR500 GLN506

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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