Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 545 |
| PDBID: | 3JBD |
| Chains: | 7_1 |
| Organism: | Human poliovirus 1 Mahoney, Camelus dromedarius |
| Method: | EM |
| Resolution (Å): | 4.80 |
| Reference: | 10.1128/JVI.03017-15 |
| Antibody | |
| Antibody: | PVSP6A VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | poliovirus capsid protein VP1 |
| Antigen mutation: | No |
| Durg Target: | P03300 |
Sequence information
Antibody
Chain: 7
Mutation: NULL
| >3JBD_7|Chain E[auth 7]|nanobody VHH PVSP6A|Camelus dromedarius (9838) QVQLQESGGGSAQTGGSLRLSCAASGFTFSHGYMAWFRQAPEKEREWVACVRTSGVSAYYADSVLGRFTISQDNAKSTLYLQMNNLKPEDTAMYYCAATSISCSSGYMFWGQGTQVTVSSHHHHHH |
Antigen
Chain: 1
Mutation: NULL
| >3JBD_1|Chain A[auth 1]|Capsid protein VP1|Human poliovirus 1 Mahoney (12081) GLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESFFARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYVPPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGILAVRVVNDHNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| 7: GLN39 GLU42 LYS43 GLU44 1: SER295 THR296 LYS297 ASP298 THR301 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
