Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 543 |
| PDBID: | 3JBC |
| Chains: | 7_3 |
| Organism: | Human poliovirus 1 Mahoney, Camelus dromedarius |
| Method: | EM |
| Resolution (Å): | 6.50 |
| Reference: | 10.1128/JVI.03017-15 |
| Antibody | |
| Antibody: | PVSP29F VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | poliovirus capsid protein VP3 |
| Antigen mutation: | No |
| Durg Target: | P03300 |
Sequence information
Antibody
Chain: 7
Mutation: NULL
| >3JBC_7|Chain E[auth 7]|nanobody VHH PVSP29F|Camelus dromedarius (9838) QVQLQESGGGSVQTGGSLRLSCAASEYTQSSACMGWFRQAPGKEREGVAGISRFFGTAYYADSVKGRFTISQDKAKNTVYLQMNSLKPEDTAIYYCAAGQGCLTTIQALGGAYGYNAWGQGTQVTVSSHHHHHH |
Antigen
Chain: 3
Mutation: NULL
| >3JBC_3|Chain C[auth 3]|Capsid protein VP3|Human poliovirus 1 Mahoney (12081) GLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDDPILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFLFCGSMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGLQSSCTMVVPWISNTTYRQTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| 7: GLN1 GLN5 GLU26 TYR27 THR28 GLN29 GLN100 ASN116 3: LYS62 SER91 PRO93 ILE180 ASP181 ASP182 SER183 THR229 HIS230 GLU232 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
