Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 542 |
| PDBID: | 3JBA |
| Chains: | HL_A |
| Organism: | Mus musculus, Human papillomavirus 16 |
| Method: | EM |
| Resolution (Å): | 12.00 |
| Reference: | 10.1128/JVI.02020-15 |
| Antibody | |
| Antibody: | H16.U4 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Major capsid protein L1 from Human papillomavirus type 16 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3JBA_H|Chain B[auth H]|H16.U4 antibody heavy chain|Mus musculus (10090) SGGGLVKPGGSLKLSCEASGFTFSSYAMSWVRQTPEKRLEWVASISSGGNTHYPDSVKGRFTISRDNARNILYLQMSSLRSEDTAMYYCARGLYYGYDEGSDFDYWGQGTTLTVS |
Light Chain: L
Mutation: NULL
| >3JBA_L|Chain A[auth L]|H16.U4 antibody light chain|Mus musculus (10090) DIVMSQSPSSLAVSVGEKVTMSCKSSQSLLYSNTQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVKAEDLAVYYCQQYYSYPLTFGAGTKLELKRA |
Antigen
Chain: A
Mutation: NULL
| >3JBA_A|Chain C[auth A], D[auth B], E[auth C], F[auth D], G[auth E], H[auth F]|Major capsid protein L1|Human papillomavirus type 16 (333760) ATVYLPPVPVSKVVSTDEYVARTNIYYHAGTSRLLAVGHPYFPIKKPNNNKILVPKVSGLQYRVFRIHLPDPNKFGFPDTSFYNPDTQRLVWACVGVEVGRGQPLGVGISGHPLLNKLDDTENASAYAANAGVDNRECISMDYKQTQLCLIGCKPPIGEHWGKGSPCTQVAVQPGDCPPLELINTVIQDGDMVDTGFGAMDFTTLQANKSEVPLDICTSICKYPDYIKMVSEPYGDSLFFYLRREQMFVRHLFNRAGTVGENVPDDLYIKGSGSTANLASSNYFPTPSGSMVTSDAQIFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMSLCAAISTSETTYKNTNFKEYLRHGEEYDLQFIFQLCKITLTADVMTYIHSMNSTILEDWNFGLQPPPGGTLEDTYRFVTSQAIACQKHTPPAPKEDPLKKYTFWEVNLKEKFSADLDQFPLGRKFLLQLGLKAKPKFTLGKRK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR28 SER30 SER31 SER53 ASN56 HIS58 ASP61 LYS64 ARG83 TYR97 GLY99 A: LYS171 GLY172 SER173 GLU189 ILE191 ASN192 THR193 THR211 THR212 SER227 PRO434 PRO436 LYS437 LYS443 THR445 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
