Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5357 |
| PDBID: | 7WKX |
| Chains: | AC_F |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.81 |
| Reference: | 10.1016/j.ijbiomac.2022.01.119 |
| Antibody | |
| Antibody: | HB0017 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-17A |
| Antigen mutation: | No |
| Durg Target: | Q16552 |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7WKX_A|Chain A, B|Heavy chain of HB0017 Fab|Homo sapiens (9606) QVQLVQSGSELKKPGASVKVSCKASEYIFTNYGMNWVKQAPGQGFEWMGWIDTNTGEPTYAQGFTGRFVFSLDTSVSTAYLQISSLKAEDTATYYCANYGWGYFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVSA |
Light Chain: C
Mutation: NULL
| >7WKX_C|Chain C, D|Light chain of HB0017 Fab|Homo sapiens (9606) DVVMTQTPPSLPVNPGEPASISCRSSQSLVHSNGYTYLHWYLQKPGQSPQLLIYKVSNHLSGVPDRFSGSGSGTDFTLKISWVEAEDVGVYFCSQSTHVPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: F
Mutation: NULL
| >7WKX_F|Chain E, F|Interleukin-17A|Homo sapiens (9606) MGHHHHHHENLYFQGIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TYR27 PHE29 ASN31 TYR32 TRP50 THR53 ASN54 THR55 GLU57 THR59 TYR99 TRP101 GLY102 TYR103 C: HIS31 ASN33 TYR35 TYR37 TYR54 LYS55 SER96 VAL99 TYR101 F: LEU49 ILE51 HIS52 ASN53 ARG78 GLU80 ASP81 PRO82 GLU83 ARG84 TYR85 SER87 VAL88 LEU122 ARG124 PRO127 HIS128 PRO130 ASN131 PHE133 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
