Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5329 |
| PDBID: | 7WG3 |
| Chains: | HD_L |
| Organism: | Mus musculus, Bos taurus |
| Method: | XRD |
| Resolution (Å): | 2.19 |
| Reference: | 10.1016/j.celrep.2022.111555 |
| Antibody | |
| Antibody: | D9 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Bos taurus interleukin-17B receptor |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7WG3_H|Chain E, F, G, H|Heavy chain of D9 Fab|Mus musculus (10090) EVQLQQSGPELVKPGASVKISCKTSGYTFTEYTIHWVKQNHGKSLDWIGGINPNNGGTTYNQEFKGKATLTVDKSSSTAYMEFRSLTSEDSAVYYCARSYYGYVDYWGQGTTLTAAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKAEPKSCD |
Light Chain: D
Mutation: NULL
| >7WG3_D|Chain A, B, C, D|Light chain of D9 Fab|Mus musculus (10090) QIVLTQSPAIMSASPGEKVTMTCSASSSIYYIHWYQQKSGTSPKRWIYDTSKLASGVPARFSGSGSGTSYSLTISSMEAEDAATYYCQQWSSNPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: L
Mutation: NULL
| >7WG3_L|Chain I, J, K, L|IL17RB protein|Bos taurus (9913) PEPTIQCGSEPGPSPEWMVRHTLTPGDLRDLRVETIKSNVDLEDSPILMNISWILRADASIRLLKATKICVMGKSHFQSYSCIRCNYTQAFQTQTRPSGGKWTFSYVGFPVELNTVYFIGAHNIPNANMNEDGPSMAVNFTSPGCLDHVMKYKKKCIEAGSLWKPNITACKRSANTVEVNFTTSPLGDRYMALIQSTAVIGTSYVSEKELTRTSVVVHVTGESEGAVVQLTPYFHTCGNDCIRQRGTVVQCPQTG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: TYR30 TYR31 HIS33 ASP49 TRP90 SER91 SER92 ASN93 H: THR28 THR30 GLU31 THR33 GLY50 ASN52 ASN54 ASN55 GLY57 THR58 THR59 TYR100 TYR101 GLY102 L: VAL19 ARG20 HIS21 THR22 LEU23 THR24 PRO25 GLY26 ASP27 LEU28 ARG29 ASP30 ARG32 LYS101 VAL116 PHE118 VAL138 ASN139 PHE140 THR141 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
