Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 53 |
| PDBID: | 1H0D |
| Chains: | BA_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1016/s0969-2126(03)00131-x |
| Antibody | |
| Antibody: | 26-2F Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Angiogenin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >1H0D_B|Chain B|ANTIBODY FAB FRAGMENT, HEAVY CHAIN|HOMO SAPIENS (9606) EVMLVESGGGLVKPGGSLKLSCAASGFTFSSYTMSWVRQTPEKRLEWVATISSGGGNTYYPDSVKGRFTISRDIAKNTLYLQMSSLRSEDTALYYCTRLGDYGYAYTMDYWGQGTSVTVSSAKTTPPSVYPLAPGGGGGGGAMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPWPSETVTCNVAHPASSTKVDKKIVPRDC |
Light Chain: A
Mutation: NULL
| >1H0D_A|Chain A|ANTIBODY FAB FRAGMENT, LIGHT CHAIN|HOMO SAPIENS (9606) DIVLTQSPASLAVSLGQRATISCRASESVDNYGISFMSWFQQKPGQPPKLLIYAASNQGSGVPARFSGSGSGTDFSLNIHPMEEDDTAMYFCQQSKEVPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVRWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHAASPIVKSFNRNEC |
Antigen
Chain: C
Mutation: NULL
| >1H0D_C|Chain C|ANGIOGENIN|HOMO SAPIENS (9606) QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: PHE32 SER90 LYS91 GLU92 VAL93 LEU95 B: THR33 THR50 SER52 GLY53 ASN56 TYR58 LEU95 TYR98 C: GLY34 LEU35 SER37 PRO38 CYS39 LYS40 ASP41 LEU83 GLY85 GLY86 SER87 PRO88 TRP89 PRO90 PRO91 GLN93 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
