Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5298 |
| PDBID: | 7VYT |
| Chains: | HL_T |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.53 |
| Reference: | 10.1080/19420862.2021.2013750 |
| Antibody | |
| Antibody: | anti-TIGIT MG1131 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | T-cell immunoreceptor with Ig and ITIM domains |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7VYT_H|Chain B, E[auth H]|MG1131 heavy chain variable region|Homo sapiens (9606) MEVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGIINPSGGSTSYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCASRSGSGWFGALDYWGQGTLVTVSS |
Light Chain: L
Mutation: NULL
| >7VYT_L|Chain D[auth C], F[auth L]|MG1131 light chain variable region|Homo sapiens (9606) GGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPGGTFGQGTKVEIKRVDKLA |
Antigen
Chain: T
Mutation: NULL
| >7VYT_T|Chain A, C[auth T]|T-cell immunoreceptor with Ig and ITIM domains|Homo sapiens (9606) MTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLES |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER0 ILE2 SER29 SER30 SER31 TYR32 GLY92 SER93 SER94 H: TYR33 ILE50 SER56 THR57 SER58 TYR59 GLN61 GLN64 GLY99 T: THR55 GLN56 ASN58 GLU60 GLN62 ASP63 GLN64 LEU65 ILE68 ASN70 ASP72 LEU73 GLY74 TRP75 HIS76 ILE109 HIS111 THR112 TYR113 PRO114 ASP115 GLY116 THR117 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
