Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5290 |
| PDBID: | 7VNG |
| Chains: | HL_D |
| Organism: | Human coronavirus 229E, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.80 |
| Reference: | 10.1038/s42003-022-04160-8 |
| Antibody | |
| Antibody: | S11 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human coronavirus 229E spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7VNG_H|Chain B[auth H]|S11 Fab heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFNISSSYIHWVRQAPGKGLEWVASIYSSYGYTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARWWITFGGAGGGLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV |
Light Chain: L
Mutation: NULL
| >7VNG_L|Chain C[auth L]|S11 Fab light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQGYAWRNTFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: D
Mutation: NULL
| >7VNG_D|Chain A[auth D]|Spike glycoprotein S1|Human coronavirus 229E (11137) PVYHKHTFIVLYVDFKPQSGGGKCFNCYPAGVNITLANFNETKGPLCVDTSHFTTKYVAVYANVGRWSASINTGNCPFSFGKVNNFVKFGSVCFSLKDIPGGCAMPIVANWAYSKYYTIGSLYVSWSDGDGITGVPQPVEGVENLYFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR33 TYR52 TYR55 TYR57 THR58 TYR59 ILE101 THR102 PHE103 GLY104 GLY105 ALA106 L: ASP1 ILE2 SER28 VAL29 SER30 SER31 ALA32 TYR49 SER50 SER52 ARG66 GLN90 TYR92 TRP94 ARG95 D: GLU334 THR335 LYS336 GLY337 PRO338 CYS340 VAL341 ASP342 THR343 GLY383 SER384 CYS386 LYS390 ASP391 ILE392 PRO393 GLY394 GLY395 SER418 TRP419 SER420 ASP421 GLY422 GLY424 ILE425 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
