Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5284 |
| PDBID: | 7VGR |
| Chains: | DC_A |
| Organism: | Mus musculus, Severe acute respiratory syndrome coronavirus 2 |
| Method: | EM |
| Resolution (Å): | 2.70 |
| Reference: | 10.1038/s41467-022-32019-3 |
| Antibody | |
| Antibody: | YN7756_1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 membrane protein dimer (long form) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >7VGR_D|Chain B[auth D], D[auth F]|YN7756_1 Fab heavy chain|Mus musculus (10090) EVQLQQSGAELVRPGSSVKISCKGSGYVFSNYWMNWVKQRPGQGLEWIGQIYPGDGDTNYNGKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYFCASGYLGENYVMDFWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSS |
Light Chain: C
Mutation: NULL
| >7VGR_C|Chain A[auth C], C[auth E]|YN7756_1 Fab light chain|Mus musculus (10090) DIVLTQSPASLTVSLGQRATISCRASESVDSFGNSFMHWYQQKPGQPPKLLIYRASNLESGIPARFSGSGSRTDFTLTINPVEADDVATYYCQQSSEDPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >7VGR_A|Chain E[auth A], F[auth B]|Membrane protein|Severe acute respiratory syndrome coronavirus 2 (2697049) MHHHHHHHHDYKDDDDKENLYFQGMADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: SER31 PHE32 ASN34 PHE36 ARG54 D: VAL28 ASN31 TYR32 TRP33 TYR52 GLY54 ASP55 ASP57 ASN59 TYR100 LEU101 GLY102 GLU103 ASN104 TYR105 A: LEU138 VAL139 PRO165 LYS166 ARG174 THR175 LYS180 LEU181 GLY182 ALA183 SER184 ARG186 PHE193 ALA195 SER197 ARG198 TYR199 ARG200 ILE201 TYR204 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
