Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5273 |
| PDBID: | 7V0P |
| Chains: | GH_d |
| Organism: | Eastern equine encephalitis virus, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 5.20 |
| Reference: | 10.1073/pnas.2213690120 |
| Antibody | |
| Antibody: | IgG-106 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Eastern equine encephalitis virus spike glycoprotein E2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >7V0P_G|Chain E, G, I, K|IgG 106 Fab heavy chain|Homo sapiens (9606) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAAA |
Light Chain: H
Mutation: NULL
| >7V0P_H|Chain F, H, J, L|IgG 106 Fab light chain|Homo sapiens (9606) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX |
Antigen
Chain: d
Mutation: NULL
| >7V0P_d|Chain M[auth a], N[auth b], O[auth c], P[auth d]|Spike glycoprotein E2|Eastern equine encephalitis virus (11021) DLDTHFTQYKLARPYIADCPNCGHSRCDSPIAIEEVRGDAHAGVIRIQTSAMFGLKTDGVDLAYMSFMNGKTQKSIKIDNLHVRTSAPCSLVSHHGYYILAQCPPGDTVTVGFHDGPNRHTCTVAHKVEFRPVGREKYRHPPEHGVELPCNRYTHKRADQGHYVEMHQPGLVADHSLLSIHSAKVKITVPSGAQVKYYCKCPDVREGITSSDHTTTCTDVKQCRAYLIDNKKWVYNSGRLPRGEGDTFKGKLHVPFVPVKAKCIATLAPEPLVEHKHRTLILHLHPDHPTLLTTRSLGSDANPTRQWIERPTTVNFTVTGEGLEYTWGNHPPKRVWAQESGE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: UNK55 UNK56 UNK57 UNK58 UNK59 UNK102 UNK103 UNK104 UNK105 UNK107 H: UNK28 UNK29 UNK30 UNK31 UNK32 UNK50 UNK91 UNK92 UNK93 UNK94 d: HIS181 LYS184 LYS186 VAL204 ARG205 GLU206 GLY207 ILE208 THR209 SER210 SER211 ASP212 HIS213 THR215 THR216 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
