Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5253 |
| PDBID: | 7V05 |
| Chains: | Aa_X |
| Organism: | Mus musculus, Plasmodium falciparum |
| Method: | EM |
| Resolution (Å): | 3.40 |
| Reference: | 10.1371/journal.ppat.1010999 |
| Antibody | |
| Antibody: | 850 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium falciparum circumsporozoite protein (PfCSP) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7V05_A|Chain A, BA[auth B], C, E[auth D], G[auth E], I[auth F], K[auth G], M[auth H], O[auth I], R[auth J], T[auth K], V[auth L], X[auth M], Z[auth N]|850 Fab Heavy Chain|Mus musculus (10090) QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGMHWIRQSPGKGLEWVAIIWYDGSNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKVWFGESEDNYSVDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: a
Mutation: NULL
| >7V05_a|Chain AA[auth a], B[auth b], CA[auth c], D[auth d], F[auth e], H[auth f], J[auth g], L[auth h], N[auth i], P[auth j], S[auth k], U[auth l], W[auth m], Y[auth n]|850 Fab Light Chain|Mus musculus (10090) DIQMTQSPSTLSTSVGDRVTITCRASQSISNWLAWYQQKPGKAPKLLIYKASTLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYSSYWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: X
Mutation: NULL
| >7V05_X|Chain Q[auth X]|Circumsporozoite protein|Plasmodium falciparum (5833) FQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDGNNEDNEKLRKPKHKKLKQPADGNPDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANSAVKNNNNEEPSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEKCSSVFNVVQSSPHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASN31 PHE32 GLY33 ILE50 TYR52 TYR58 VAL95 TRP96 PHE97 a: TYR91 SER92 SER93 TYR94 TRP95 X: ALA106 ASN107 PRO108 ASN109 ALA110 ASN111 PRO112 ASN113 ALA114 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
