Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5252 |
| PDBID: | 7UZD |
| Chains: | HL_A |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1016/j.immuni.2022.10.019 |
| Antibody | |
| Antibody: | HSW-2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7UZD_H|Chain B[auth H]|HSW-2 Fab heavy chain|Mus musculus (10090) QVQLQQSGPELVKPGASVKISCKASGYVFSTSWMSWVKQRPGEGPEWIGRIYPRDGHSSSTGKFKDKATLTADKSSNTAYIHLSSLTSEDSAVYFCARDYGYYYFDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Light Chain: L
Mutation: NULL
| >7UZD_L|Chain C[auth L]|HSW-2 Fab light chain|Mus musculus (10090) DIQMTQSPASLSASVGEAVTITCRLSENVYSFLAWYQQKQGKSPQLLVYRAKTLAEGVPSRFSGSGSGTQFSLKINSLQPEDFGTYYCQHHYGTPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7UZD_A|Chain A|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) MGWSCIILFLVATATGVHSRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR36 TRP38 ARG55 TYR57 ASP62 HIS64 ARG106 TYR108 GLY109 TYR110 TYR113 TYR114 ASP116 TYR117 L: ILE2 GLU27 TYR36 PHE38 TYR55 ARG56 GLU69 HIS107 TYR108 GLY109 THR114 A: GLY381 VAL382 SER383 LYS386 ASP389 LEU390 CYS391 PHE392 THR393 THR430 PHE515 LEU517 LEU518 HIS519 ALA520 PRO521 ALA522 CYS525 LYS528 LYS529 SER530 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
