Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5231 |
| PDBID: | 7UYM |
| Chains: | HL_K |
| Organism: | Mus musculus, Lama glama, Plasmodium falciparum |
| Method: | XRD |
| Resolution (Å): | 2.20 |
| Reference: | 10.1371/journal.ppat.1010999 |
| Antibody | |
| Antibody: | 850 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium falciparum circumsporozoite peptide (NANPNANPNANP ) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7UYM_H|Chain A[auth H]|850 Fab Heavy Chain|Mus musculus (10090) QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGMHWIRQSPGKGLEWVAIIWYDGSNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKVWFGESEDNYSVDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >7UYM_L|Chain C[auth L]|850 Fab Light Chain|Mus musculus (10090) DIQMTQSPSTLSTSVGDRVTITCRASQSISNWLAWYQQKPGKAPKLLIYKASTLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYSSYWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: K
Mutation: NULL
| >7UYM_K|Chain B[auth K]|VHH nanobody|Lama glama (9844) XVQLXXSGGGXVQXGXSLXLSCXAXXXXXXXXXXXWXRQXPGXXREXVXXXXXXXXXXXXXDSXXGRFTXSXDXXXXXXXLQXXXLXXXDXAXYYCXXXXXXXXXXXXXXWGXGTXVTVSS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition L: LEU11 SER12 LYS106 ARG107 THR108 VAL109 TYR139 PRO140 GLU142 ALA143 LYS144 THR196 HIS197 GLN198 GLY199 LEU200 SER201 K: UNK33 UNK35 UNK37 ARG45 UNK47 UNK50 UNK52 UNK55 UNK57 UNK58 UNK59 UNK60 UNK61 ASP62 UNK65 UNK99 UNK101 UNK103 UNK104 UNK105 UNK106 UNK107 UNK108 TRP111 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
