Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5227 |
| PDBID: | 7UVS |
| Chains: | AB_C |
| Organism: | Homo sapiens, Plasmodium falciparum |
| Method: | XRD |
| Resolution (Å): | 2.06 |
| Reference: | 10.1016/j.immuni.2023.01.013 |
| Antibody | |
| Antibody: | LMIV230-02 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium falciparum gametocyte surface protein P230 domain 1 (Pfs230D1) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7UVS_A|Chain A, D|LMIV230-02 Fab heavy chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCKASGGTFNSYGISWVRQAPGQGLEWVGGIIPSFGTADYAQKFQGRVTFTTDTSTSTAYMEVSSLRSEDTAVYYCAGSSWSSGTYYGRSAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: B
Mutation: NULL
| >7UVS_B|Chain B, E|LMIV230-02 Fab light chain|Homo sapiens (9606) EIVMTQSPASLALSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAGDVAVYHCQQYYSTPYSFGQGTKLEIKRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >7UVS_C|Chain C, F|Gametocyte surface protein P230|Plasmodium falciparum (5833) VGVDELDKIDLSYETTESGDTAVSEDSYDKYASQNTNKEYVCDFTDQLKPTESGPKVKKCEVKVNEPLIKVKIICPLKGSVEKLYDNIEYVPKKSPYVVLTKEETKLKEKLLSKLIYGLLISPTVNEKENNFKEGVIEFTLPPVVHKATVFYFICDNSKTEDDNKKGNRGIVEVYVEPYGGSLKENLYFQGWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: SER31 SER53 PHE54 THR56 SER96 TRP97 SER98 SER99 B: GLU1 SER27 ASN28 ASN29 LYS30 TYR32 TRP50 SER52 THR53 TYR92 SER93 C: ASP555 GLU556 LEU557 ASP558 LEU619 LYS645 SER646 PRO647 TYR648 SER664 TYR668 GLY669 LEU670 LEU671 ILE672 SER673 PRO674 THR675 GLU678 GLU680 ASN681 ASN682 LYS684 THR691 PRO693 PRO694 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
