Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5220 |
| PDBID: | 7UVF |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1007/s00259-022-05968-6 |
| Antibody | |
| Antibody: | ZED8 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human T-cell surface glycoprotein CD8 alpha chain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7UVF_H|Chain C[auth H], F[auth X]|Immunoglobulin heavy chain|Homo sapiens (9606) EVQLVQSGAEVKKPGASVKVSCKASGFNIKDTYIHWVRQAPGQGLEWIGRIDPANDNTLYASKFQGRATITADTSTSTAYLELSSLRSEDTAVYYCGRGYGYYVFDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >7UVF_L|Chain D[auth L], E[auth Y]|Immunoglobulin light chain|Homo sapiens (9606) DVQITQSPSSLSASVGDRVTITCRTSRSISQYLAWYQEKPGKTNKLLIYSGSTLQSGIPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQVNEFPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7UVF_A|Chain A, B|T-cell surface glycoprotein CD8 alpha chain|Homo sapiens (9606) SQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSNSIMYFSHFVPVFLPAKPTTTPGNSHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: LYS30 ASP31 THR32 TYR33 ARG50 ALA53 LEU58 TYR97 GLY98 TYR99 L: ARG27 SER28 SER30 TYR32 SER50 VAL91 ASN92 GLU93 PHE94 PRO96 A: ASN13 LEU14 GLY15 ARG40 ASP83 ARG85 ARG86 GLU87 GLU89 LEU112 PRO113 ALA114 LYS115 PRO116 THR117 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
