Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5218 |
| PDBID: | 7USV |
| Chains: | C_A |
| Organism: | Plasmodium falciparum 3D7, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 2.10 |
| Reference: | 10.1042/BCJ20220554 |
| Antibody | |
| Antibody: | F10 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium falciparum protein Pfs230 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >7USV_C|Chain C, D|Nanobody F10|Vicugna pacos (30538) QVQLQESGGGLVQAGGSLRLSCAASGRTFSDYFMGWFRQAPGKEREFVAAVSWSGGSTYYADSVKGRFTISRDNAKNTVFLQMNSLKPEDTAVYYCAGGGSYYPMSPYDGMDYWGKGTQVTVSSHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >7USV_A|Chain A, B|Gametocyte surface protein P230|Plasmodium falciparum (36329) GASTNKEYVCDFTDQLKPTESGPKVKKCEVKVNEPLIKVKIICPLKGSVEKLYDNIEYVPKKSPYVVLTKEETKLKEKLLSKLIYGLLISPTVNEKENNFKEGVIEFTLPPVVHKATVFYFICDNSKTEDDNKKGNRGIVEVYVEPYG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: SER30 ASP31 PHE33 SER52 TRP53 SER54 GLY56 SER57 THR58 TYR59 GLY100 SER101 TYR102 TYR103 PRO104 MET105 SER106 A: THR587 ASN588 LYS589 GLU590 TYR591 VAL592 CYS593 ASP594 PHE595 GLN598 LYS609 LYS610 CYS611 GLU612 LYS614 ASN616 GLU617 ILE620 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
