Complex | |
AACDB_ID: | 5217 |
PDBID: | 7UST |
Chains: | B_A |
Organism: | Vicugna pacos, Plasmodium falciparum 3D7 |
Method: | XRD |
Resolution (Å): | 1.70 |
Reference: | 10.1042/BCJ20220554 |
Antibody | |
Antibody: | F5 VHH |
Antibody mutation: | No |
INN (Clinical Trial): | |
Antigen | |
Antigen: | Plasmodium falciparum protein Pfs230 |
Antigen mutation: | No |
Durg Target: |
Antibody
Chain: B
Mutation: NULL
>7UST_B|Chain A[auth B]|Nanobody F5|Vicugna pacos (30538) QVQLQESGGGLVQPGGSLRLSCAASGFTLDRYAIGWFRQAPGKEREGVSCISSSDGSTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCARDHGPCTVLADILYDYGMDYWGKGTQVTVSSHHHHHH |
Antigen
Chain: A
Mutation: NULL
>7UST_A|Chain B[auth A]|Gametocyte surface protein P230|Plasmodium falciparum (36329) GASTNKEYVCDFTDQLKPTESGPKVKKCEVKVNEPLIKVKIICPLKGSVEKLYDNIEYVPKKSPYVVLTKEETKLKEKLLSKLIYGLLISPTVNEKENNFKEGVIEFTLPPVVHKATVFYFICDNSKTEDDNKKGNRGIVEVYVEPYG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
B: ARG31 GLU44 ARG45 GLU46 SER53 ASP99 HIS100 GLY101 PRO102 CYS103 THR104 LEU106 ALA107 ILE109 TYR111 TYR113 GLY114 ASP116 A: PRO606 LYS607 VAL608 LYS610 VAL642 LEU651 LYS653 THR656 LYS657 LEU658 LYS659 GLU660 TYR703 ILE705 ASP707 SER709 LYS710 ARG720 ILE722 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)