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Entry information

Complex
AACDB_ID: 5217
PDBID: 7UST
Chains: B_A
Organism: Vicugna pacos, Plasmodium falciparum 3D7
Method: XRD
Resolution (Å): 1.70
Reference: 10.1042/BCJ20220554
Antibody
Antibody: F5 VHH
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Plasmodium falciparum protein Pfs230
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Chain: B
Mutation: NULL

>7UST_B|Chain A[auth B]|Nanobody F5|Vicugna pacos (30538)
QVQLQESGGGLVQPGGSLRLSCAASGFTLDRYAIGWFRQAPGKEREGVSCISSSDGSTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCARDHGPCTVLADILYDYGMDYWGKGTQVTVSSHHHHHH

Antigen

Chain: A
Mutation: NULL

>7UST_A|Chain B[auth A]|Gametocyte surface protein P230|Plasmodium falciparum (36329)
GASTNKEYVCDFTDQLKPTESGPKVKKCEVKVNEPLIKVKIICPLKGSVEKLYDNIEYVPKKSPYVVLTKEETKLKEKLLSKLIYGLLISPTVNEKENNFKEGVIEFTLPPVVHKATVFYFICDNSKTEDDNKKGNRGIVEVYVEPYG

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

B: ARG31 GLU44 ARG45 GLU46 SER53 ASP99 HIS100 GLY101 PRO102 CYS103 THR104 LEU106 ALA107 ILE109 TYR111 TYR113 GLY114 ASP116

A: PRO606 LYS607 VAL608 LYS610 VAL642 LEU651 LYS653 THR656 LYS657 LEU658 LYS659 GLU660 TYR703 ILE705 ASP707 SER709 LYS710 ARG720 ILE722

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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