Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5172 |
| PDBID: | 7UMM |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/Solomon Islands/3/2006(H1N1)), Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.36 |
| Reference: | 10.1016/j.celrep.2022.111628 |
| Antibody | |
| Antibody: | Ab109 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus Solomon Islands/3/2006 H1N1(H1 SI-06 FLsE) hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7UMM_H|Chain D[auth H], E[auth I], F[auth J]|ab109 Fab heavy chain|Mus musculus (10090) QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYIHWVRQAPGQGLEWMGWINPNTGGTVYAQTFQARVTMTRDTSISTAYMELIRLRSDDTAVYYCARERGTGAPDAFNIWGQGTLVTVSGASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >7UMM_L|Chain G[auth L], H[auth M], I[auth N]|ab109 Fab light chain|Mus musculus (10090) DIVMTQSPASLAVSLGQRATISCRASKSVSTSGYSYIHWYQQKPGQPPKLLIYLATNLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCQHSRDTPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7UMM_A|Chain A, B, C|Hemagglutinin|Influenza A virus (A/Solomon Islands/3/2006(H1N1)) (464623) ADPGYLLEDTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSWPNHTTTGVSASCSHNGESSFYKNLLWLTGKNGLYPNLSKSYANNKEKEVLVLWGVHHPPNIGDQRALYHTENAYVSVVSSHYSRKFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRGFGSGIINSNAPMDECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPSIQSRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNKLERRMENLNKKVDDGFIDIWTYNAELLVLLENERTLDFHDSNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCNDECMESVKNGTYDYPKYSEESKLNREKIDGVRSGSGGALEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR33 TRP50 ASN52 VAL59 GLN62 GLU99 THR102 GLY103 ALA104 PRO105 L: ASP1 LYS27 THR31 SER32 GLY33 TYR34 TYR36 ARG96 ASP97 THR98 TYR100 A: THR135 GLY138 THR159 GLY160 LYS161 ASN162 GLY163 ASN191 ILE192 GLY193 ASP194 ARG196 ALA197 LEU198 HIS200 GLU202 LYS223 LYS226 ASP229 GLN230 GLU231 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
