Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5168 |
| PDBID: | 7UL5 |
| Chains: | D_A |
| Organism: | Homo sapiens, Lama glama |
| Method: | EM |
| Resolution (Å): | 3.10 |
| Reference: | 10.1038/s41594-022-00859-8 |
| Antibody | |
| Antibody: | Nb6 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human somatostatin receptor type 2 |
| Antigen mutation: | No |
| Durg Target: | P30874 |
Sequence information
Antibody
Chain: D
Mutation: NULL
| >7UL5_D|Chain B[auth D]|Nanobody 6|Lama glama (9844) MAQVQLQESGGGLVQAGESLRLSCAASGTIFRLYDMGWYRRVSGNQRELVASITSGGSTKYGDSVKGRFTISRDNAKNTVYLQMSSLKPEDTAVYYCNAEYRTGIWEELLDGWGQGTQVTVSSHHHHHHEPEA |
Antigen
Chain: A
Mutation: NULL
| >7UL5_A|Chain A|Somatostatin receptor type 2|Homo sapiens (9606) DYKDDDDAMGQPGNGSAFLLAPNRSHAPDHDVENLYFQGMDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSVRLLSGSREKDRNLRRVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSILEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: PHE31 ARG32 TYR34 ASP35 GLU100 ARG102 ILE105 TRP106 GLU107 GLU108 LEU109 LEU110 ASP111 A: TYR228 ILE231 ILE232 VAL235 LYS236 SER237 VAL238 ARG239 LEU240 ARG245 ASP248 ARG249 ARG252 ARG253 THR255 ARG256 SER259 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
