Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5120 |
| PDBID: | 7U8M |
| Chains: | NO_C |
| Organism: | Influenza A virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 5.39 |
| Reference: | 10.1073/pnas.2200821119 |
| Antibody | |
| Antibody: | FluA-20 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H15N9 - HK14 H3 chimeric cH15/3 hemagglutinin HA1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: N
Mutation: NULL
| >7U8M_N|Chain M[auth N], O[auth Q], Q[auth T]|antibody FluA-20 Fab heavy chain|Homo sapiens (9606) QVQLEESGPGLVKPSETLSLTCSVSGVSVTSDIYYWTWIRQPPGKGLEWIGYIFYNGDTNYNPSLKSRVTMSIDTSKNEFSLRLTSVTAADTAVYFCARGTEDLGYCSSGSCPNHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: O
Mutation: NULL
| >7U8M_O|Chain N[auth O], P[auth R], R[auth U]|antibody FluA-20 Fab light chain|Homo sapiens (9606) DIVMTQSPSSLSASIGDRVTITCRPSQNIRSFLNWFQHKPGKAPKLLIYAASNLQSGVPSRFSGSGSGTEFTLTIRSLQPEDFATYYCQQSYNTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >7U8M_C|Chain A, E[auth C], I[auth G]|hemagglutinin HA1 subunit|Influenza A virus (11320) DPGATLCLGHHAVPNGTIVKTITNDRIEVTNATELVQNSSIGEICTKGKKAVDLGSCGILGTIIGPPQCDLHLEFKADLIIERRNSSDICYPGRFTNEEALRQIIRESGGIDKESMGFRYSGIRTDGATSACKRTVSSFYSEMKWLSSSMNNQVFPQLNQTYRNTRKEPALIVWGVHHSSSLDEQNKLYGTGNKLITVGSSKYQQSFSPSPGARPKVNGQAGRIDFHWMLLDPGDTVTFTFNGAFIAPDRATFLRSNAPSGIEYNGKSLGIQSDAQIDESCKSECFTPNGSIPNDKPFQNVNRITYGACPRYVKHSTLKLATGMRNVPEKQTR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| N: GLN1 ASP32 ILE33 TYR34 ARG94 THR96 GLU97 ASP98 LEU99 ASN101 O: PHE32 LEU46 TYR49 ASN53 LEU54 GLN55 SER56 SER67 C: ARG91 ASN92 ILE96 PRO99 GLY100 ARG101 SER216 PRO217 GLY218 ALA219 ARG220 PRO221 LYS222 VAL223 ASN224 ARG229 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
