Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5115 |
| PDBID: | 7U8M |
| Chains: | HL_C |
| Organism: | Influenza A virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 5.39 |
| Reference: | 10.1073/pnas.2200821119 |
| Antibody | |
| Antibody: | 31.a.83 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H15N9 - HK14 H3 chimeric cH15/3 hemagglutinin HA1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7U8M_H|Chain D[auth F], H, L[auth K]|antibody 31.a.83 Fab heavy chain|Homo sapiens (9606) EVQLLESGGGLVQPGESLRVSCAASGFTFRDSALSWVRQAPGKGLEWVSAISGNGGATYYADTVKGRFTISRDNSQTTLYLQMNSLRADDTATYYCAKDESPPIYNLMPGYYSTYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: L
Mutation: NULL
| >7U8M_L|Chain C[auth E], G[auth J], K[auth L]|Antibody 31.a.83 Fab light chain|Homo sapiens (9606) EIVMTQSPVTLSVSPGETATLSCRASQSVRSNLAWYQQKPGQAPRLLIYGASTRATDIPARFSGSGSGTEFTLSISSLQSDDFAVYYCQQYNHWLRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >7U8M_C|Chain A, E[auth C], I[auth G]|hemagglutinin HA1 subunit|Influenza A virus (11320) DPGATLCLGHHAVPNGTIVKTITNDRIEVTNATELVQNSSIGEICTKGKKAVDLGSCGILGTIIGPPQCDLHLEFKADLIIERRNSSDICYPGRFTNEEALRQIIRESGGIDKESMGFRYSGIRTDGATSACKRTVSSFYSEMKWLSSSMNNQVFPQLNQTYRNTRKEPALIVWGVHHSSSLDEQNKLYGTGNKLITVGSSKYQQSFSPSPGARPKVNGQAGRIDFHWMLLDPGDTVTFTFNGAFIAPDRATFLRSNAPSGIEYNGKSLGIQSDAQIDESCKSECFTPNGSIPNDKPFQNVNRITYGACPRYVKHSTLKLATGMRNVPEKQTR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ILE2 GLN27 SER28 TYR91 ASN92 HIS93 TRP94 C: ILE25 LYS27 ASN31 ASP32 ARG33 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
