Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5111 |
| PDBID: | 7U8L |
| Chains: | HL_A |
| Organism: | Influenza A virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 4.56 |
| Reference: | 10.1073/pnas.2200821119 |
| Antibody | |
| Antibody: | 31.a.83 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H15N9 - HK14 H3 chimeric cH15/3 hemagglutinin HA1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7U8L_H|Chain D[auth H]|antibody Fab heavy chain|Homo sapiens (9606) EVQLLESGGGLVQPGESLRVSCAASGFTFRDSALSWVRQAPGKGLEWVSAISGNGGATYYADTVKGRFTISRDNSQTTLYLQMNSLRADDTATYYCAKDESPPIYNLMPGYYSTYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: L
Mutation: NULL
| >7U8L_L|Chain C[auth L]|Antibody Fab light chain|Homo sapiens (9606) EIVMTQSPVTLSVSPGETATLSCRASQSVRSNLAWYQQKPGQAPRLLIYGASTRATDIPARFSGSGSGTEFTLSISSLQSDDFAVYYCQQYNHWLRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7U8L_A|Chain A|Hemagglutinin HA1 subunit|Influenza A virus (11320) DPGATLCLGHHAVPNGTIVKTITNDRIEVTNATELVQNSSIGEICTKGKKAVDLGSCGILGTIIGPPQCDLHLEFKADLIIERRNSSDICYPGRFTNEEALRQIIRESGGIDKESMGFRYSGIRTDGATSACKRTVSSFYSEMKWLSSSMNNQVFPQLNQTYRNTRKEPALIVWGVHHSSSLDEQNKLYGTGNKLITVGSSKYQQSFSPSPGARPKVNGQAGRIDFHWMLLDPGDTVTFTFNGAFIAPDRATFLRSNAPSGIEYNGKSLGIQSDAQIDESCKSECFTPNGSIPNDKPFQNVNRITYGACPRYVKHSTLKLATGMRNVPEKQTR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: VAL13 GLY16 GLU17 THR18 THR20 ARG30 SER52 ARG54 ALA60 SER63 GLY64 SER76 A: HIS18 ASN38 THR40 LYS54 GLY55 LYS83 TYR261 ASN262 GLU280 ASN290 THR318 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
