Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5094 |
| PDBID: | 7TZ5 |
| Chains: | IL_A |
| Organism: | Homo sapiens, Influenza A virus (A/New York/01/2010(H3N2)) |
| Method: | EM |
| Resolution (Å): | 3.41 |
| Reference: | 10.1128/jvi.00896-22 |
| Antibody | |
| Antibody: | TJ5-5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 COBRA hemagglutinin TJ5 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >7TZ5_I|Chain A[auth H], B[auth I], C[auth J]|TJ5-5 heavy chain|Homo sapiens (9606) VQLVQSGAEVKKPGSSVKVSCKASGVTFTYYTISWVRQAPGQGLEWMGGIMPMFGTPNYAQKFQGRVTITADEPTSTIYMMLSSLRSEDTAVYYCASLGNYESGGYHPYFEYWGHGTLVTVSS |
Light Chain: L
Mutation: NULL
| >7TZ5_L|Chain D[auth L], E[auth M], F[auth N]|TJ5-5 light chain|Homo sapiens (9606) SVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVHWYQQLPGTAPRLLIYGNSNRPSGVPDRFSGSRSGTSASLAITGLQAEDEADYYCQSYDNSLSGSGVFGGGTKL |
Antigen
Chain: A
Mutation: NULL
| >7TZ5_A|Chain G[auth A], H[auth B], I[auth C]|Hemagglutinin|Influenza A virus (1287827) NSTATLCLGHHAVPNGTIVKTITNDQIEVTNATELVQSSSTGEICDSPHQILDGENCTLIDALLGDPQCDGFQNKKWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWTGVTQNGTSSACIRRSNNSFFSRLNWLTHLNFKYPALNVTMPNNEQFDKLYIWGVHHPGTDKDQIFLYAQASGRITVSTKRSQQAVIPNIGSRPRVRNIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCNSECITPNGSIPNDKPFQNVNRITYGACPRYVKQSTLKLATGMRNVPEKQTRGIFGAIAGFIENGWEGMVDGWYGFRHQNSEGRGQAADLKSTQAAIDQINGKLNRLIGKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTKKQLRENAEDMGNGCFKIYHKCDNACIGSIRNGTYDHDVYRDEALNNRFQI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| I: VAL28 THR29 PHE30 THR35 TYR36 TYR37 THR38 MET57 PRO58 MET59 PHE62 GLY63 THR64 GLU82 LEU107 GLY108 ASN109 TYR110 HIS112 PRO113 L: ALA35 GLY36 TYR37 TYR107 ASN109 LEU112 SER113 SER115 A: TYR98 THR131 GLY134 THR135 SER136 SER137 ASN144 ASN145 TRP153 THR155 HIS156 ASN158 PHE159 LYS160 HIS183 THR187 LYS189 ASP190 ILE192 PHE193 LEU194 ALA196 GLN197 ALA198 ARG222 ASN225 ILE226 PRO227 SER228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
