Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5089 |
| PDBID: | 7TXW |
| Chains: | HL_A |
| Organism: | Mus musculus, Plasmodium falciparum 3D7 |
| Method: | XRD |
| Resolution (Å): | 2.17 |
| Reference: | 10.1038/s41541-023-00655-5 |
| Antibody | |
| Antibody: | 1G2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium falciparum 3D7 ookinete surface protein P25 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7TXW_H|Chain B[auth H]|Fab fragment of monoclonal antibody 1G2 heavy chain|Mus musculus (10090) QVQLQQSGAELVRPGASVTLSCKASGYTFTDYEMHWVKQTPVHGLEWIGAIDPETGGPAYNQKFKGKAILTTDKSSTTAYMELRSLTSEDSAVYYCARYYYVSSYWGQGTSVTVSSASTKPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCG |
Light Chain: L
Mutation: NULL
| >7TXW_L|Chain A[auth L]|Fab fragment of monoclonal antibody 1G2 light chain|Mus musculus (10090) DVVMTQTPLSLPVSLGDQASMSCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVSKRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPYTFGGGTKLEMKRTDAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >7TXW_A|Chain C[auth A]|Ookinete surface protein P25|Plasmodium falciparum 3D7 (36329) KVTVDTVCKRGFLIQMSGHLECKCENDLVLVNEETCEEKVLKCDEKTVNKPCGDFSKCIKIDGNPVSYACKCNLGYDMVNNVCIPNECKNVTCGNGKCILDTSNPVKTGVCSCNIGKVPNVQDQNKCSKDGETKCSLKCLKENETCKAVDGIYKCDCKDGFIIDNESSICT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: VAL30 HIS31 SER32 ASN33 GLY34 ASN35 TYR37 TYR54 LYS55 LYS58 PHE60 SER61 H: THR28 ASP31 TYR32 ARG98 TYR100 TYR101 VAL102 SER104 A: VAL29 LYS31 ARG32 GLU47 ASN48 ASP49 LEU50 GLU59 GLU60 LYS61 VAL62 LEU63 LYS64 ASP66 LYS68 THR69 LYS72 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
