Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5085 |
| PDBID: | 7TTY |
| Chains: | HL_A |
| Organism: | Bat SARS-like coronavirus WIV1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.11 |
| Reference: | 10.1126/scitranslmed.abn6859 |
| Antibody | |
| Antibody: | 10-40 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Sarbecovirus bat WIV1 RBD |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7TTY_H|Chain B[auth H]|1040 heavy chain|Homo sapiens (9606) QLQLQESGPGLVKPSETLSLTCTVSGGSISSSNFYWGWIRQPPGKGLEWIASITYSGRTFYNPSLKSRVAISVDTSKNQFSLKLSSVTAADTAVYYCARTFPSYYDRSGYHYLNYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSXXXSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >7TTY_L|Chain C[auth L]|1040 light chain|Homo sapiens (9606) NFMLTQPHSMSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSSWVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT |
Antigen
Chain: A
Mutation: NULL
| >7TTY_A|Chain A|Spike protein S1|Bat SARS-like coronavirus WIV1 (1415852) NLCPFGEVFNATTFPSVYAWERKRISNCVADYSVLYNSTSFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFTGCVLAWNTRNIDATQTGNYNYKYRSLRHGKLRPFERDISNVPFSPDGKPCTPPAFNCYWPLNDYGFYITNGIGYQPYRVVVLSFELLNAPATVCGPKK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLN1 GLY26 GLY27 SER28 SER30 SER31 SER32 ASN33 PHE34 ARG94 PHE96 PRO97 SER98 TYR99 ASP101 L: TYR32 TYR49 GLU50 GLN53 ARG54 PRO55 SER56 A: TYR369 ASN370 SER371 THR372 PHE374 PHE377 LYS378 CYS379 TYR380 GLY381 VAL382 SER383 ALA384 THR385 ASP405 ARG408 GLN409 ALA411 PRO412 GLY413 GLN414 THR415 GLY416 ASP427 ASP428 PHE429 LYS460 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
