Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5082 |
| PDBID: | 7TRI |
| Chains: | ZY_B |
| Organism: | Influenza A virus (A/Sydney/5/1997(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.60 |
| Reference: | 10.1371/journal.pbio.3002415 |
| Antibody | |
| Antibody: | S8V1-172 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus Sydney/5/1997 H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: Z
Mutation: NULL
| >7TRI_Z|Chain C[auth Z]|S8V1-172 Fab heavy chain|Homo sapiens (9606) EVQLQESGPGLVKPSETLSLTCTVSGGSISNYHWTWIRQPPGKGLEWIGDMYNSGSTKYNPSLKSRVTISVDRSKNQLSLKLSSVTVADTAVYYCARDDIVIGEGWYHGMDLWGQGTTVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: Y
Mutation: NULL
| >7TRI_Y|Chain B[auth Y]|S8V1-172 Fab kappa light chain|Homo sapiens (9606) EIVLTQSPATLSLSPGERATLSCRASQSVSTDLAWYQQKPGQAPRLLIYDAISRASGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQHRSTWVTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >7TRI_B|Chain A[auth B]|Hemagglutinin|Influenza A virus (A/Sydney/5/1997(H3N2)) (587884) TNATELVQSSSTGRICDSPHRILDGENCTLIDALLGDPHCDGFQNKEWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWTGVAQNGTSYACKRSSIKSFFSRLNWLHQLKYKYPALNVTMPNNDKFDKLYIWGVHHPSTDSDQTSIYAQASGRVTVSTKRSQQTVIPNIGSRPWVRGISSRISIHWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCNSECITPNGSIPNDKPFQNVNRITYGACPRYVKQNTLKLATGALEVLFQVKQN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Y: SER30 THR31 ASP32 ASP50 ILE52 SER56 SER67 Z: ASN31 TYR32 HIS33 ASN53 SER54 ARG97 ASP98 ASP99 ILE100 VAL101 ILE102 GLY103 GLU104 GLY105 TRP106 HIS108 ASP111 B: TYR98 GLY134 THR135 SER136 TYR137 SER143 ILE144 LYS145 TRP153 HIS155 GLN156 LYS158 TYR159 HIS183 SER186 SER189 ASP190 THR192 SER193 ILE194 ALA196 GLY225 ILE226 SER227 SER228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
