Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5080 |
| PDBID: | 7TR4 |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.30 |
| Reference: | 10.1038/s41587-022-01567-w |
| Antibody | |
| Antibody: | MA2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HLA-A*02:01 |
| Antigen mutation: | No |
| Durg Target: | P04439 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7TR4_H|Chain C[auth H]|Light chain|Homo sapiens (9606) QSELTQPRSVSGSPGQSVTISCTGTDRDVGGQNYVSWYQQHPGKAPKLIIHDVIERSSGVPDRFSGSKSGNTASLTISGLQAEDEADYYCWSPAWPYAVFGTGTDVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC |
Light Chain: L
Mutation: NULL
| >7TR4_L|Chain D[auth L]|Heavy chain|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFSTYQMSWVRQAPGKGLEWVSGIVSSGGSTAYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAGELLPGYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Antigen
Chain: A
Mutation: NULL
| >7TR4_A|Chain A|HLA-A*02:01|Homo sapiens (9606) GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEPSS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLN1 ASP26 ARG27 GLY30 GLY31 GLN32 ASN33 TYR34 ASP52 GLU55 TRP95 L: LEU101 PRO102 TYR104 A: GLU58 GLY62 ARG65 LYS66 LYS68 ALA69 HIS70 GLN72 THR73 VAL76 LYS146 ALA149 ALA150 HIS151 GLU154 GLN155 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
