Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5072 |
| PDBID: | 7TP4 |
| Chains: | HL_Z |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Macaca mulatta |
| Method: | XRD |
| Resolution (Å): | 1.95 |
| Reference: | 10.1126/scitranslmed.abl9605 |
| Antibody | |
| Antibody: | K398.22 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7TP4_H|Chain B[auth H]|K398.22 heavy chain|Macaca mulatta (9544) EVQLAESGGGLVKPGGSLRLSCVASGFTFSSNEMHWVRQAPGKGLEWVSVISESGFTTEYADSVKGRFTISRDNAKNSLFLQMNSLRAEDTAVYYCTRVSIFGQFIVATYFDYWGQGVLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: L
Mutation: NULL
| >7TP4_L|Chain C[auth L]|K398.22 light chain|Macaca mulatta (9544) QAALTQPRSVSGSPGQSVTISCTGTSSDIGGYNYVSWYQQHPGTAPKLMIYAVSERPSGVSDRFSGSKSGNTASLTISGLQAEDEADYYCCSYAGTVLFGGGTRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: Z
Mutation: NULL
| >7TP4_Z|Chain A[auth Z]|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLU33 VAL50 SER52 GLU53 SER54 PHE56 THR57 THR58 GLU59 ASP62 LYS65 ILE101 GLN104 PHE105 ILE106 L: GLY31 TYR32 TYR34 TYR93 ALA94 GLY95 THR96 Z: SER373 PHE374 SER375 ARG403 GLY404 ASP405 ARG408 ASN437 ASN439 VAL445 GLN498 PRO499 THR500 ASN501 GLY502 VAL503 GLY504 TYR505 GLN506 TYR508 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
