Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5071 |
| PDBID: | 7TP3 |
| Chains: | HL_Z |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Macaca mulatta |
| Method: | XRD |
| Resolution (Å): | 2.33 |
| Reference: | 10.1126/scitranslmed.abl9605 |
| Antibody | |
| Antibody: | K288.2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7TP3_H|Chain B[auth H]|K288.2 heavy chain|Macaca mulatta (9544) EVRLVESGGGLVKPGGSLRLSCVASGFTFSSYEMHWVRQAPGKGLEWVSVISESGATTHYTDSVKGRFTISRDNAKNSLFLQMNSLRAEDTAVYYCTRPQSVTVFGVAATSYEAFDFWGQGLRVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: L
Mutation: NULL
| >7TP3_L|Chain C[auth L]|K288.2 light chain|Macaca mulatta (9544) DIVMTQSPDTLSLSPGETATLSCRASQSVSSYVAWYQQKPEQPPRLLIYGSSSRATGMPDRFSGSGSGTDFTLTISSLEPDDFAVYYCQQYTNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECS |
Antigen
Chain: Z
Mutation: NULL
| >7TP3_Z|Chain A[auth Z]|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFSGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: GLU33 VAL50 SER52 GLU53 SER54 ALA56 THR57 THR58 HIS59 ASP62 LYS65 VAL102 ALA108 ALA109 THR110 SER111 TYR112 GLU113 L: SER30 TYR32 THR92 ASN93 TRP94 Z: ALA372 SER373 PHE374 SER375 GLY404 ASP405 ARG408 ASN437 ASN439 ASN440 VAL445 GLY496 GLN498 PRO499 THR500 ASN501 GLY502 VAL503 GLY504 TYR505 GLN506 TYR508 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
