Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5066 |
| PDBID: | 7TN9 |
| Chains: | QR_W |
| Organism: | Mus musculus, Ebola virus - Mayinga, Zaire, 1976 |
| Method: | EM |
| Resolution (Å): | 3.10 |
| Reference: | 10.1016/j.chom.2023.01.002 |
| Antibody | |
| Antibody: | REGN 3479 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Ebola virus envelope glycoprotein GP2 |
| Antigen mutation: | No |
| Durg Target: | Q05320 |
Sequence information
Antibody
Heavy Chain: Q
Mutation: NULL
| >7TN9_Q|Chain I[auth M], J[auth O], N[auth Q]|REGN3479 heavy chain|Mus musculus (10090) EVQLVESGGGLVQPGGSLRLSCAASGFTSSSYAMNWVRQAPGKGLEWVSTISGMGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKRGYPHSFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVE |
Light Chain: R
Mutation: NULL
| >7TN9_R|Chain E[auth N], F[auth P], M[auth R]|REGN3479 light chain|Mus musculus (10090) DIQMTQSPSSLSASVGDRVTITCRASQSISSFLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTLTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: W
Mutation: NULL
| >7TN9_W|Chain H[auth V], O[auth W], P[auth X]|GP2|Ebola virus - Mayinga, Zaire, 1976 (128952) AIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDDDDDK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| R: SER30 SER31 PHE32 SER91 TYR92 SER93 THR94 LEU95 Q: TRP47 THR50 THR58 TYR59 TYR60 LYS65 ARG99 TYR101 PRO102 HIS103 W: ASP522 GLU523 GLY524 ALA525 ALA526 ILE527 GLY528 LEU529 ALA530 TRP531 PHE535 GLY536 PRO537 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
