Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 5011 |
| PDBID: | 7TE6 |
| Chains: | CD_B |
| Organism: | Xenopus laevis, Rattus norvegicus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 4.55 |
| Reference: | 10.1038/s41467-022-28559-3 |
| Antibody | |
| Antibody: | anti-GluN2B Fab5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Glutamate receptor ionotropic, NMDA 2B |
| Antigen mutation: | No |
| Durg Target: | Q13224 |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >7TE6_C|Chain C, G|Fab5 heavy chain|Mus musculus (10090) DVKLQESGGGSVKLGGSLKLSCVVSGFTFSTYYMSWVRQTPEKRLELVAVINSNGGNTYYPDNVKGRFTISRDNAENTLYLQMSSLKSEDTALYYCARRDYDGFAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDC |
Light Chain: D
Mutation: NULL
| >7TE6_D|Chain D, H|Fab5 light chain|Mus musculus (10090) DIQLTQSPASLAVSLGQRATISCRASQSVSTSRYSYMHWYQHKPGQPPKLLIKYASNLESGVPARFSGSGSGTDFTLNIHPVEEEDTATYYCQHSWENPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR |
Antigen
Chain: B
Mutation: NULL
| >7TE6_B|Chain B, F|Glutamate receptor ionotropic, NMDA 2B|Rattus norvegicus (10116) SPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRDLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRM |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: TYR33 VAL50 ILE51 ASN52 SER53 GLY56 ASN57 TYR59 ASP100 TYR101 ASP102 GLY103 PHE104 D: THR31 SER32 ARG33 TYR34 TYR36 TYR54 SER95 TRP96 GLU97 ASN98 TYR100 B: PRO33 LYS137 ASP138 GLU139 SER141 PHE144 LEU308 SER309 GLU310 HIS311 SER312 PHE313 ILE314 PRO315 GLU316 GLN331 SER332 ASN333 MET334 ASN336 ARG337 TYR338 ILE340 GLU353 ASP354 GLY355 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
