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Entry information

Complex
AACDB_ID: 4998
PDBID: 7TC9
Chains: HL_B
Organism: Homo sapiens
Method: EM
Resolution (Å): 5.08
Reference: 10.1126/science.abn8897
Antibody
Antibody: A19-46.1 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: SARS-CoV-2 B.1.1.529 VOC spike glycoprotein RBD
Antigen mutation: No
Durg Target: P0DTC2

Sequence information

Antibody

Heavy Chain: H
Mutation: NULL

>7TC9_H|Chain B[auth H]|Heavy chain of antibody A19-46.1|Homo sapiens (9606)
QVQLVESGGGVVQPGRSLRLSCAASGFTLSSYGMHWVRQAPGKGLEWVAVISYDGSNKYYVDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGWAYWELLPDYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK

Light Chain: L
Mutation: NULL

>7TC9_L|Chain C[auth L]|Light chain of antibody A19-46.1|Homo sapiens (9606)
QTVVTQEPSFSVSPGGTVTLTCGLSSGSVSTAYFPSWYQQTPGQAPRTLIYGTNTRSSGVPDRFSGSILGNKAALTITGAQADDESDYYCVLYMGRGIVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

Antigen

Chain: B
Mutation: NULL

>7TC9_B|Chain A[auth B]|Spike protein S1|Homo sapiens (9606)
ITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNLAPFFTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYSFRPTYGVGHQPYRVVVLSFELLHAPATVCG

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

H: ALA101 TRP103 GLU104 LEU105 LEU106 PRO107 TYR111

L: SER26 SER28 SER30 THR31 ALA32 TYR33 PHE34 THR53 ASN54 THR55 SER67 MET94 GLY95 ARG96

B: THR345 ARG346 PHE347 ALA348 SER349 TYR351 ALA352 LYS444 VAL445 SER446 TYR449 ASN450 TYR451 LEU452 ILE468 THR470 VAL483 ALA484 GLY485 PHE490 LEU492 ARG493 SER494

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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