Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4983 |
| PDBID: | 7T7B |
| Chains: | HL_A |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.59 |
| Reference: | 10.1038/s42003-022-03700-6 |
| Antibody | |
| Antibody: | ADI-62113 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7T7B_H|Chain B[auth H]|ADI-62113 Fab heavy chain|Homo sapiens (9606) QVQLQQSGAEVKKPGASVKLSCKASGYTFSVFPIHWVRQAPGQRLEWMGWHNAGDGDTKYSQKFQGRVTIISDTSASTAYMELSSLKSEDTAVYYCARAARPYYDRRGYFFRADYFQHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: L
Mutation: NULL
| >7T7B_L|Chain C[auth L]|ADI-62113 Fab light chain|Homo sapiens (9606) DIQVTQSPSSLSASVGDRVTITCQASQDIKNSLNWYQQKPGKAPKLLISDASNLETGVPSRFSGNGSGTDFTFTISSLQPEDIATYYCQQYDNLITFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECS |
Antigen
Chain: A
Mutation: NULL
| >7T7B_A|Chain A|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: TYR27 THR28 VAL31 PHE32 ARG94 ALA96 ARG97 PRO98 TYR99 GLN101 HIS102 L: SER49 ASP50 ASN53 GLU55 THR56 A: TYR369 ASN370 SER371 ALA372 PHE374 PHE377 LYS378 CYS379 TYR380 GLY381 VAL382 SER383 PRO384 THR385 ARG408 GLN409 PRO412 GLY413 GLN414 THR415 GLY416 ASP427 ASP428 PHE429 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
