Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4962 |
| PDBID: | 7T17 |
| Chains: | JK_C |
| Organism: | Homo sapiens, Zika virus |
| Method: | EM |
| Resolution (Å): | 5.26 |
| Reference: | 10.1016/j.cell.2022.10.023 |
| Antibody | |
| Antibody: | DH1017 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zika virus envelope glycoprotein E |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: J
Mutation: NULL
| >7T17_J|Chain C[auth F], E[auth J]|DH1017.IgM IgH|Homo sapiens (9606) QVQLQESGPGLVKPSQTLSLTCAVSGGSISSGDSYWSWIRQHPGKGLEWIGSIYYSGSTYYNPSLKSRVTIPIDTSKNQFSLKLSSVTAADTAVYYCARHVGDLRVNDAFDIWGQGTMVTVSS |
Light Chain: K
Mutation: NULL
| >7T17_K|Chain D[auth G], F[auth K]|DH1017.IgM IgL|Homo sapiens (9606) QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNFVSWYQRLPGTPPKLLIYDSDKRPSGIPDRFSGSKSGTSATLGITGLQTGDEGDYYCGTWDRSLSVVVFGGGTKLTVL |
Antigen
Chain: C
Mutation: NULL
| >7T17_C|Chain G[auth A], H[auth C], I[auth E]|Core protein|Zika virus (64320) IRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPTVDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFACSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIVNDTGHETDENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| J: GLY26 GLY27 SER28 GLY32 ASP33 THR75 SER76 ASN78 GLY102 ASP103 LEU104 ARG105 VAL106 C: ALA120 CYS121 SER122 LYS123 LYS124 THR126 THR205 ASN207 ASN208 THR231 GLY232 THR233 PRO234 ASP278 GLY279 ALA280 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
