Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4961 |
| PDBID: | 7T17 |
| Chains: | FG_A |
| Organism: | Homo sapiens, Zika virus |
| Method: | EM |
| Resolution (Å): | 5.26 |
| Reference: | 10.1016/j.cell.2022.10.023 |
| Antibody | |
| Antibody: | DH1017 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zika virus envelope glycoprotein E |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: F
Mutation: NULL
| >7T17_F|Chain C[auth F], E[auth J]|DH1017.IgM IgH|Homo sapiens (9606) QVQLQESGPGLVKPSQTLSLTCAVSGGSISSGDSYWSWIRQHPGKGLEWIGSIYYSGSTYYNPSLKSRVTIPIDTSKNQFSLKLSSVTAADTAVYYCARHVGDLRVNDAFDIWGQGTMVTVSS |
Light Chain: G
Mutation: NULL
| >7T17_G|Chain D[auth G], F[auth K]|DH1017.IgM IgL|Homo sapiens (9606) QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNFVSWYQRLPGTPPKLLIYDSDKRPSGIPDRFSGSKSGTSATLGITGLQTGDEGDYYCGTWDRSLSVVVFGGGTKLTVL |
Antigen
Chain: A
Mutation: NULL
| >7T17_A|Chain G[auth A], H[auth C], I[auth E]|Core protein|Zika virus (64320) IRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPTVDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFACSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIVNDTGHETDENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| F: GLY27 SER28 SER30 SER31 GLY32 ASP33 SER34 TYR35 TYR55 SER56 SER58 THR59 SER76 LYS77 VAL101 GLY102 ASP103 LEU104 A: TYR61 GLU62 ALA63 SER64 ILE65 SER66 ALA120 SER122 LYS123 LYS124 MET125 THR126 THR205 MET206 ASN207 ASN208 ALA229 THR231 GLY232 GLU262 MET277 GLY279 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
