Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4958 |
| PDBID: | 7T0L |
| Chains: | HL_B |
| Organism: | Homo sapiens, synthetic construct, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | W6/32 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HLA-B*27:05 |
| Antigen mutation: | No |
| Durg Target: | P61769 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7T0L_H|Chain G, H|IgG2a heavy chain|Mus musculus (10090) VQLKQSGPGLVQPSQSLSLTCTVSGFSLTSYGVHWVRQPPGKGLEWLGVIWSGGSTDYNAAFISRLSIRKDNSKSQVFFKMNSLQADDTAIYYCARTFTTSTSAWFAYWGQGTLVTVSAAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEP |
Light Chain: L
Mutation: NULL
| >7T0L_L|Chain I[auth K], J[auth L]|Light chain kappa|Mus musculus (10090) SIVMTQTPKFLLVSAGDRVTITCKASQSVSNDVAWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSGYGTDFTFTISTVQAEDLAVYFCQQDYSSPPWTFGGGTKLEIRRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFN |
Antigen
Chain: B
Mutation: NULL
| >7T0L_B|Chain B, E|Beta-2-microglobulin|Homo sapiens (9606) IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: SER30 TRP51 SER52 SER55 THR56 ASP57 THR100 SER101 THR102 SER103 L: GLN28 ASP33 ASP92 TYR93 SER94 SER95 PRO96 TRP98 B: ILE1 GLN2 ARG3 THR4 LYS6 SER28 GLY29 HIS31 LYS58 ASP59 TRP60 SER61 THR86 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
