Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4955 |
| PDBID: | 7T0L |
| Chains: | GK_D |
| Organism: | Homo sapiens, synthetic construct, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | W6/32 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HLA-B*27:05 |
| Antigen mutation: | No |
| Durg Target: | P01889 |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >7T0L_G|Chain G, H|IgG2a heavy chain|Mus musculus (10090) VQLKQSGPGLVQPSQSLSLTCTVSGFSLTSYGVHWVRQPPGKGLEWLGVIWSGGSTDYNAAFISRLSIRKDNSKSQVFFKMNSLQADDTAIYYCARTFTTSTSAWFAYWGQGTLVTVSAAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEP |
Light Chain: K
Mutation: NULL
| >7T0L_K|Chain I[auth K], J[auth L]|Light chain kappa|Mus musculus (10090) SIVMTQTPKFLLVSAGDRVTITCKASQSVSNDVAWYQQKPGQSPKLLIYYASNRYTGVPDRFTGSGYGTDFTFTISTVQAEDLAVYFCQQDYSSPPWTFGGGTKLEIRRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFN |
Antigen
Chain: D
Mutation: NULL
| >7T0L_D|Chain A, D|MHC class I antigen|Homo sapiens (9606) GSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAPWIEQEGPEYWDRETQISKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYGCDVGPDGRLLRGYHQNAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition G: SER18 LEU19 THR20 THR29 GLY53 GLY54 SER55 TYR58 SER67 ILE68 ARG69 LYS70 ASP71 SER73 LYS74 PHE78 LYS80 PHE98 THR99 THR100 SER101 THR102 SER103 K: SER31 ASN32 ASP33 TYR50 TYR51 SER53 ASN54 TYR68 D: TYR85 ASN86 GLN87 SER88 HIS93 ASP119 GLY120 LYS121 ASP122 THR134 ALA136 ASP137 THR138 GLU212 THR214 GLU222 ASP223 THR225 GLN226 ASP227 THR228 GLU229 LEU230 GLU232 LYS243 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
