Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4949 |
| PDBID: | 7SWD |
| Chains: | JK_C |
| Organism: | Ebola virus - Gabon (1994-1997), Zaire ebolavirus, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.59 |
| Reference: | 10.1016/j.cell.2022.02.023 |
| Antibody | |
| Antibody: | 1C3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Ebola virus virion spike glycoprotein GP1 lacking the mucin-like domain |
| Antigen mutation: | No |
| Durg Target: | Q05320 |
Sequence information
Antibody
Heavy Chain: J
Mutation: NULL
| >7SWD_J|Chain J|1C3 heavy chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVACKVSGGTFSSYTISWVRQAPGQGLEWMGGIIPSFGVGHYSQKFRDRVTLTADKSTTTAFLELSSVRSEDTALYYCAILGTFNWKSGGNYFGPWGQGTLVTVSS |
Light Chain: K
Mutation: NULL
| >7SWD_K|Chain K|1C3 light chain|Homo sapiens (9606) DIVLTQSPDSLAASLGERATISCKSSHSVLYSSNNKDFFAWYQQKPGQPPKLLISWASTRESGVPVRFNGGGSGTHFTLTISSLQAEDVAVYYCQQYFSSPITFGQGTRLEIKRT |
Antigen
Chain: C
Mutation: NULL
| >7SWD_C|Chain A, C, E|Virion spike glycoprotein GP1|Ebola virus - Gabon (1994-1997) (128947) IPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTVVS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition K: LEU30 SER33 ASN34 ASN35 ASP37 SER58 THR59 ARG60 VAL66 ASN69 GLY70 GLY71 GLY72 SER73 C: LYS114 PRO116 ASP117 GLY118 SER119 GLU120 CYS121 LEU122 PRO123 ALA124 ASP150 PHE151 ARG172 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
