Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4940 |
| PDBID: | 7ST5 |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.20 |
| Reference: | 10.1158/2767-9764.CRC-23-0634 |
| Antibody | |
| Antibody: | CC-95251 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Anzurstobart(Phase-I) |
| Antigen | |
| Antigen: | Human tyrosine-protein phosphatase non-receptor type substrate 1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7ST5_H|Chain A[auth H], D[auth h]|Fab CC-95251 anti-SIRP-alpha heavy chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGYTFRGYGISWVRQAPGQGLEWMGWISAYGGETNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCAREAGSSWYDFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH |
Light Chain: L
Mutation: NULL
| >7ST5_L|Chain B[auth L], E[auth l]|Fab CC-95251 anti-SIRP-alpha light chain|Homo sapiens (9606) DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYAASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGASFPITFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7ST5_A|Chain C[auth A], F|Tyrosine-protein phosphatase non-receptor type substrate 1|Homo sapiens (9606) EEELQVIQPDKSVLVAAGETATLRCTATSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRIGNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSSGLVPR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR28 GLY31 TYR32 GLY33 TRP50 SER52 TYR54 GLY55 GLU57 THR58 ASN59 GLU99 ALA100 GLY101 SER102 SER103 TRP104 TYR105 ASP106 ASP108 L: SER30 SER31 TRP32 LEU46 TYR49 ALA50 ASN53 GLN55 ALA92 SER93 PHE94 A: LEU30 ILE31 PRO32 VAL33 GLY34 PRO35 GLN52 LYS53 GLU54 GLY55 LEU66 THR67 LYS68 ARG69 PHE74 ARG95 LYS96 GLY97 SER98 PRO99 ASP101 VAL102 PHE104 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
