Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4933 |
| PDBID: | 7SQ1 |
| Chains: | HL_E |
| Organism: | Human immunodeficiency virus 1, Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.80 |
| Reference: | 10.1038/s41467-022-28363-z |
| Antibody | |
| Antibody: | C05 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV BG505.MD39TS envelope glycoprotein -gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7SQ1_H|Chain F[auth A], J[auth H]|C05 Fab heavy chain|Mus musculus (10090) EVKLEESGGGLVQAGGSMKLSCVASGFSLSNYWMNWVRQSPEKGLEWVAEIRLKPQNYATHYAESVKGRFSISRDDSRSTVYLQMNNLRAEDTGIYYCTRPGYYGHYAMDYWGQGTSVTVSS |
Light Chain: L
Mutation: NULL
| >7SQ1_L|Chain E[auth I], I[auth L]|C05 Fab Light chain|Mus musculus (10090) DIVLTQSPASLAVSPGQRATISCRPSESVDNYGISFMNWFQQKPGQPPKLLIYAASNRGSGVPARFTGSGSGTDFSLNIHPMEEDDIAMYFCQQSKEVPYTFGGGTKLEIK |
Antigen
Chain: E
Mutation: NULL
| >7SQ1_E|Chain B[auth C], D[auth E], H[auth G]|Envelope glycoprotein gp160|Human immunodeficiency virus 1 (11676) ENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQAFYYTGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ILE30 PHE32 SER91 LYS92 VAL94 TYR96 H: ASN31 TYR32 TRP33 PRO52 GLN53 ASN54 ALA56 HIS58 PRO95 GLY96 TYR97 TYR98 GLY99 E: ILE277 THR278 ARG350 LYS351 HIS352 PHE353 GLY354 ASN355 ASN356 THR357 ILE358 ARG360 THR394 ILE396 SER397 ASN398 VAL401 GLN402 ARG456 SER460 THR461 ASN462 SER463 THR464 THR465 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
