Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 491 |
| PDBID: | 3G6D |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1016/j.jmb.2009.03.076 |
| Antibody | |
| Antibody: | CNTO607 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-13 |
| Antigen mutation: | No |
| Durg Target: | P35225 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3G6D_H|Chain B[auth H]|CNTO607 Fab Heavy chain|Homo sapiens (9606) QVQLVESGGGLVQPGGSLRLSCAASGFTFNSYWINWVRQAPGKGLEWVSGIAYDSSNTLYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGLGAFHWDMQPDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH |
Light Chain: L
Mutation: NULL
| >3G6D_L|Chain A[auth L]|CNTO607 Fab Light chain|Homo sapiens (9606) SYELTQPPSVSVAPGQTARISCSGDNIGGTFVSWYQQKPGQAPVLVIYDDNDRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCGTWDMVTNNVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >3G6D_A|Chain C[auth A]|Interleukin-13|Homo sapiens (9606) MGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR2 ASP25 ASN26 GLY28 GLY29 THR30 PHE31 TYR48 ASP49 ASP50 ASP52 ASN65 TRP90 ASP91 MET92 H: THR28 SER31 TYR32 TYR53 LEU100 GLY101 ALA102 PHE103 HIS104 TRP105 ASP106 GLN108 A: PRO5 PRO6 ARG11 ILE14 GLU15 VAL18 ASN19 THR21 GLN22 ASN23 GLN24 LYS25 LYS97 LEU100 LEU101 LYS104 LYS105 PHE107 ARG108 GLU109 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
