Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4903 |
| PDBID: | 7SK6 |
| Chains: | FE_A |
| Organism: | Homo sapiens |
| Method: | EM |
| Resolution (Å): | 4.00 |
| Reference: | 10.1126/sciadv.abn8063 |
| Antibody | |
| Antibody: | CID24 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human atypical chemokine receptor 3 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: F
Mutation: NULL
| >7SK6_F|Chain D[auth F]|CID24 Fab heavy chain|Homo sapiens (9606) EISEVQLVESGGGLVQPGGSLRLSCAASGFNISSSSIHWVRQAPGKGLEWVASISPSYGYTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARVSYWDWTWGWSKYEGMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT |
Light Chain: E
Mutation: NULL
| >7SK6_E|Chain C[auth E]|CID24 Fab light chain|Homo sapiens (9606) SDIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQSYYYPITFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7SK6_A|Chain A|Atypical chemokine receptor 3|Homo sapiens (9606) GAPDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTKGRPLEVLFQGPHHHHHHHHHHDYKDDDDK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: SER32 ALA33 SER51 ALA52 SER53 SER92 TYR93 TYR94 TYR95 F: VAL5 PHE30 ASN31 SER33 SER34 SER35 SER36 HIS38 SER53 ILE54 SER55 SER57 TYR58 TYR60 SER62 ARG101 VAL102 TYR104 TRP105 ASP106 TRP107 THR108 TRP109 GLY110 TRP111 SER112 LYS113 TYR114 A: VAL68 ASN69 ALA72 THR75 GLY76 TYR77 ASP78 THR79 HIS80 ILE83 MET138 ASP141 ARG142 TYR143 LEU144 SER145 ILE146 THR147 TYR148 PHE149 THR150 ASN151 THR152 PRO153 SER154 SER155 LYS157 LYS158 ARG162 LEU235 ILE239 ALA241 SER242 ASP244 GLN245 HIS248 SER249 TYR315 SER316 ASN319 ARG320 ASN321 TYR322 GLU325 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
